Glucose homeostasis
In vivo
- Insulin tolerance test, Glucose tolerance tests (intraperitoneal glucose tolerance or oral glucose tolerance).
- Euglycemic, hyperinsulinemic clamp (to assess whole-body and tissue-specific insulin action and glucose metabolism in vivo in awake, unrestrained mice).
- Hyperglycemic clamp (to assess in vivo pancreatic b-cell function - i.e., glucose-induced insulin secretion).
- Hypoglycemic, hyperinsulinemic clamp (to assess the function of counterregulatory hormones).
In vitro
- Static infusions or perifusions of Isolated islets : (to assess ex vivo pancreatic b-cell function - i.e., glucose-induced insulin secretion).
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